Search on: PYRIMIDINE DIMERS 
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Descriptor English:   Pyrimidine Dimers 
Descriptor Spanish:   Dímeros de Pirimidina 
Descriptor Portuguese:   Dímeros de Pirimidina 
Synonyms English:   Thymine Dimers  
Tree Number:   D03.383.742.686.600
D13.695.578.424.600
D13.695.740.600
Definition English:   Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION. 
See Related English:   DNA Damage
 
History Note English:   77 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   12177 
Unique Identifier:   D011740 

Occurrence in VHL: 		 

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